HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Shin-ichi Takeda Noriyoshi Sawabata Hajime Maeda Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Funakoshi, Y. Articles by Maeda, H. Search for Related Content PubMed PubMed Citation Articles by Funakoshi, Y. Articles by Maeda, H. Related Collections Lung - cancer

Long-Term Pulmonary Function after Lobectomy for Primary Lung Cancer

Division of General Thoracic Surgery, Toneyama National Hospital, Osaka, Japan

For reprint information contact: Yasunobu Funakoshi, MD Tel: 81 6 6853 2001 Fax: 81 6 6850 1750 Email: funakosy{at}toneyama.go.jp, Division of General Thoracic Surgery, Toneyama National Hospital, 5-5-1 Toneyama, Toyonaka, Osaka 560-8552, Japan.

The aim of this study was to investigate the factors affecting long-term postoperative pulmonary function with a view to increasing the application of combined resection, bronchoplasty, and induction therapy. Results in 80 patients who underwent lobectomy for primary lung cancer were analyzed. Predicted postoperative pulmonary function was calculated using the formula: postoperative predicted function = preoperative function x [1 – (b – n) /(42 – n)], where n and b are the numbers of obstructed segments and total segments, respectively, in the resected lobe. Spirometry was performed serially on the preoperative day, and at 3, 6, 12, 18, and 24 months postoperatively. The difference between the predicted postoperative pulmonary function and the function measured at 12 months postoperatively was calculated, and clinical and therapeutic variables were analyzed. Univariate analysis revealed that the difference in vital capacity was significantly related to surgical approach, bronchoplasty, and induction therapy, while the difference in forced expiratory volume in one second (FEV₁) correlated with surgical approach and induction therapy. Multiple regression analysis showed induction therapy to be the sole factor related to the differences in both vital capacity and FEV₁. Lung resection after induction therapy may cause an additional loss of pulmonary function in the late phase.

This article has been cited by other articles:

				S.-i. Takeda, Y. Funakoshi, Y. Kadota, M. Koma, H. Maeda, S. Kawamura, and Y. Matsubara Fall in diffusing capacity associated with induction therapy for lung cancer: a predictor of postoperative complication? Ann. Thorac. Surg., July 1, 2006; 82(1): 232 - 236. [Abstract] [Full Text] [PDF]