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Reappraisal of Recent Clinical Trials of Angiogenic Therapy in Myocardial Ischemia

McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada

For reprint information contact: Kevin Lachapelle, FRCSC Tel: 1 514 843 1519 Fax: 1 514 843 1603 Email: kevin.lachapelle{at}mcgill.ca, Royal Victoria Hospital, 687 Pine Ave West, Suite S8.30, Montreal H3A 1A1, Canada.

We review the clinical trials of angiogenic therapy for myocardial ischemia, focusing on why the results are unsatisfactory in more recent larger and better designed trials. Critical reappraisal of such trials, in view of the pathophysiologic complexity of the angiogenic process at a molecular level, suggests that the strategy of therapies based on a single growth factor protein or gene may not be adequate for optimal therapeutic response.