Asian Annals
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Panangipalli Venugopal
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chauhan, S.
Right arrow Articles by Venugopal, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chauhan, S.
Right arrow Articles by Venugopal, P.
Related Collections
Right arrow Cardiac - pharmacology
Asian Cardiovasc Thorac Ann 2004;12:121-124
© 2004 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTION

Dose Comparison of Tranexamic Acid in Pediatric Cardiac Surgery

Sandeep Chauhan, MD, Akshay Bisoi, MCh1, Neeraj Kumar, MD, Dinesh Mittal, MS1, Shailaja Kale, MD, Usha Kiran, MD, Panangipalli Venugopal, MCh1

Department of Cardiac Anesthesia
1 Department of Cardiac Surgery, Cardiothoracic Center, All India Institute of Medical Sciences, New Delhi, India

For reprint information contact: Sandeep Chauhan, MD Tel: 91 11 2610 8115 Fax: 91 11 2658 8641 Email: sdeep61{at}yahoo.com Cardiac Anesthesia, Cardiothoracic Centre, All-India Institute of Medical Sciences, New Delhi 110029, India.

To compare different doses of tranexamic acid, 150 consecutive children with congenital cyanotic heart disease were randomly assigned to one of 5 groups of 30 each. Group A served as a control. Group B received 50 mg·kg–1 of tranexamic acid at induction of anesthesia. Group C received 10 mg·kg–1 at induction followed by an infusion of 1 mg·kg–1·h–1. Group D had 10 mg·kg–1 at induction, 10 mg·kg–1 on bypass, and 10 mg·kg–1 after protamine. Group E had 20 mg·kg–1 at induction and again after protamine. The control group had the longest sternal closure time, the greatest blood loss in the first 24 hours, and the highest requirements for blood and blood products. Among the 4 groups given tranexamic acid, group D (triple dose) had the best results, followed by group E (double dose). Group B (single dose) had the worst results among the groups receiving tranexamic acid.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. P. Eaton
Antifibrinolytic Therapy in Surgery for Congenital Heart Disease
Anesth. Analg., April 1, 2008; 106(4): 1087 - 1100.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2004 by the Asia Publishing EXchange Ltd.