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Asian Cardiovasc Thorac Ann 2003;11:304-308
© 2003 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTION

Beneficial Effect of Aspirin on Renal Function Post-Cardiopulmonary Bypass

Rabin Gerrah, MD, Uzi Izhar, MD

Department of Cardiothoracic Surgery, Hebrew University-Hadassah Medical School, Jerusalem, Israel

For reprint information contact: Rabin Gerrah, MD Tel: 972 2 6776960 Fax: 972 2 6438005 email: rmger{at}yahoo.com Department of Cardiothoracic Surgery, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel.

Urine thromboxane, plasma creatinine, and creatinine clearance were determined perioperatively in 20 patients undergoing coronary bypass surgery. Ten patients took aspirin until the day of surgery, and 10 discontinued aspirin at least one week before surgery. A significant increase in urine thromboxane following establishment of cardiopulmonary bypass was observed only in the control group. Plasma creatinine increased in the control group on the 1st postoperative day (from 81.9 ± 13.2 to 97.6 ± 13.2 µmol•L-1, p = 0.02) and decreased next day to the preoperative level (82.7 ± 9 µmol•L-1, p = 0.03). In the aspirin group, creatinine remained unchanged on the 1st postoperative day (89.4 ± 14.2 vs. 87.2 ± 7.7 µmol•L-1, p = 0.6), and increased significantly on the 2nd day (101.4 ± 8.5 µmol•L-1, p = 0.01). The aspirin group had higher creatinine levels (p < 0.0001) and lower creatinine clearance (60.2 ± 16.5 vs. 82 ± 25.7 mL•min-1, p < 0.0001) than the control group on the 2nd postoperative day. A significant positive correlation was seen between urine thromboxane and creatinine on day 2 in both groups (r = 0.6). Aspirin administrated before coronary surgery may have a beneficial effect on renal function, probably mediated by its antiplatelet activity and thromboxane inhibition.




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J. C.J. Sun, R. Whitlock, J. Cheng, J. W. Eikelboom, L. Thabane, M. A. Crowther, and K. H.T. Teoh
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies
Eur. Heart J., April 2, 2008; 29(8): 1057 - 1071.
[Abstract] [Full Text] [PDF]


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