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Asian Cardiovasc Thorac Ann 2003;11:217-221
© 2003 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTION

Carotid Intima-Media Thickness and Coronary Artery Disease: an Indian Perspective

Gupta Hansa, MD, Kartikeya Bhargava, MD, Manish Bansal, MD, Sharad Tandon, DNB, Ravi R Kasliwal, DM

Noninvasive Cardiology, Escorts Heart Institute and Research Centre, New Delhi, India

For reprint information contact: Ravi R Kasliwal, DM Tel: 91 11 6825000 Fax: 91 11 6825013 email: rrkasliwal{at}hotmail.com Department of Cardiology, Escorts Heart Institute and Research Centre, Okhla Road, New Delhi – 110025, India.

To determine whether carotid intima-media thickness is associated with coronary artery disease and cardiovascular risk factors in the Indian population, carotid intima-media thickness was measured using high-resolution B-mode ultrasonography in 101 patients with coronary artery disease and 140 control subjects. Carotid intima-media thickness was measured at 3 predefined sites on each side. The maximum carotid intima-media thickness was significantly higher in the coronary disease group compared to the controls (1.02 vs. 0.80 mm). The average intima-media thickness was also significantly higher in the coronary disease group (0.82 vs. 0.67 mm). On multivariate logistic regression analysis, carotid intima-media thickness was the only factor found to be an independent predictor of coronary artery disease. There was a significant association between risk factor count and the average and maximum intima-media thickness values in the combined study population. These results indicate that raised values of average and maximum carotid intima-media thickness are significantly associated with the presence of coronary artery disease and this association is independent of the presence of other conventional cardiovascular risk factors.




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