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Asian Cardiovasc Thorac Ann 2003;11:153-156
© 2003 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTIONS

Tissue-Engineered Heart Valve on Acellular Aortic Valve Scaffold: In-Vivo Study

Dong-e Zhao, MD, Ruo-bing Li, MD, Wei-yong Liu, MD, Gang Wang, MD, Shi-qiang Yu, MD, Cheng-wei Zhang, MD, Wen-sheng Chen, MD, Geng-xu Zhou, MD

Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xian, People’s Republic of China

For reprint information contact: Dong-e Zhao, MD Tel: 86-10-68212211-75558 email: zhaodonge{at}hotmail.com Department of Cardiovascular Surgery, General Hospital of Armed Police Forces, Beijing 100039, People’s Republic of China.

The feasibility of constructing a tissue-engineered heart valve on an acellular porcine aortic valve leaflet was evaluated. A detergent and enzymatic extraction process was developed to remove the cellular components from porcine aortic valves. The acellular valve leaflets were seeded for 7 days in vitro with cells from canine arterial wall and endothelial cells. The constructs were implanted into the lumens of 6 canine abdominal aortas to assess the reconstruction of the valve leaflets. It was found that all cellular components had been removed from the porcine aortic valves. The valve leaflets were completely reconstructed at the end of the 10th week in vivo. Scanning electron microscopy showed that the valve leaflets were partially covered with endothelial cells. It was concluded that porcine aortic valves can be decellularized by the detergent and enzymatic extraction process and it is feasible to construct a tissue-engineered heart valve in vivo on an acellular valve scaffold.




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[Abstract] [Full Text] [PDF]


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