HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Teing Ee Tan Hugh S Paterson Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tan, T. E. Articles by Paterson, H. S Search for Related Content PubMed PubMed Citation Articles by Tan, T. E. Articles by Paterson, H. S Related Collections Myocardial protection

Intermittent Tepid Blood Cardioplegia Improves Clinical Outcome

Department of Cardiothoracic Surgery, Westmead Hospital, Department of Surgery, University of Sydney, Sydney, Australia

For reprint information contact: Hugh S Paterson, FRACS Tel: 61 2 98457994 Fax: 61 2 98458314 email: patersonH{at}aol.com Dept of Cardiothoracic Surgery, Westmead Hospital, Westmead, NSW 2151, Australia.

Intermittent antegrade cold blood cardioplegia is the predominant method of myocardial protection, but recent studies suggest that warm or tepid blood cardioplegia may improve the return of myocardial metabolic and contractile function. Data were collected prospectively on 1,533 patients undergoing cardiopulmonary bypass in a single surgeon’s practice. The use of intermittent antegrade cold (4°C) blood cardioplegia in 951 consecutive patients from September 1994 to November 1997 was compared with intermittent antegrade tepid (28°C) blood cardioplegia in 582 consecutive patients from July 1998 to July 2000. The two groups were similar, but the symptom class was more severe and there were more redo and combined procedures and more operations within 7 days of myocardial infarction in the tepid group. Significant clinical benefits identified in the tepid group included reduced usage of intraaortic balloon pumping postoperatively (4.4% versus 2.2%) and reduced incidence of postoperative atrial fibrillation (25.7% versus 20.6%). There was no significant difference in mortality, perioperative myocardial infarction, cerebrovascular events, or use of inotropics between the groups. Intermittent tepid blood cardioplegia is clinically appropriate and safe to use in patients undergoing cardiac surgery.

This article has been cited by other articles:

				K. L. Sloots, J. Vinten-Johansen, and G. P. Dobson Warm nondepolarizing adenosine and lidocaine cardioplegia: Continuous versus intermittent delivery J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1171 - 1178. [Abstract] [Full Text] [PDF]